Science

Science

Credited with an impressive record of discoveries and firsts, the StemCells, Inc. team has a distinguished heritage of scientific achievement in stem cell biology.

The Cells We Study

As stem cell science has evolved, our range of interests at StemCells, Inc. has expanded. While our therapeutic programs are focused exclusively on the transplantation of tissue-derived (adult) stem cells (HuCNS-SC® human neural stem cells) and progenitor cells (hLEC™ human liver engrafting cells), we believe there is utility in all types of stem cells and their progeny.

Today StemCells scientists study all three currently characterized types of stem cells: tissue-derived stem cells, embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, as well as progenitor cells. Molecular biology, genetic engineering and protein chemistry are core technologies for conducting this research. We consider all of these cell types as viable options both as cell-based therapies and as tools and technologies for drug discovery and development. Further scientific study will uncover the most appropriate and effective applications for each type of cell.

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Our Scientific Strength

Our scientific strength includes:

  • Our Team — StemCells scientists and Scientific Advisory Board members are recognized as world leaders in stem cell biology, credited with significant breakthroughs in the field. Learn more about our team…
  • Our Technology — A broad technology base is core to our company, spanning tissue-derived stem cells, ES cells and iPS cells, along with proprietary cell culture media, antibody reagents, molecular tools and an extensive array of unique animal models for demonstrating the authentic biological properties of human cells in target organs. Learn more about our intellectual property…
  • Our Approach — At StemCells, Inc., we encourage innovation and demand rigor. We believe that good science leads to good medicine. Learn more about our scientific approach…

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  1. Alison Motluk, Graduate Special: Make a Discovery, New Scientist, May 2008

Groundbreaking Science

The StemCells, Inc. team has an impressive record of scientific achievement.

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“Keep your eye out for unexpected results. It's almost more exciting than getting the findings you predicted.” 1
Photo

Fred Gage, PhD
Scientific Advisory Board Member

    StemCells, Inc. Scientific Achievements

  • 1999: Invented a reproducible method for growing human central nervous system (CNS) stem and progenitor cells in culture, as clusters of cells called ‘neurospheres.’ 
  • 2000: Pioneered the discovery and prospective isolation of a highly purified, expandable population of human neural stem cells
  • 2002: Pioneered the discovery and prospective isolation of a purified population of human liver engrafting cells (hLEC)
  • 2003: Demonstrated recovery of motor function in spinal cord injured animals using human neural stem cells
  • 2006: Initiated first into man US clinical trial of human neural stem cells
  • 2009: Demonstrated vision preservation in animal model of retinal degeneration using human neural stem cells
  • 2009: Published preclinical proof-of-principle for use of human neural stem cells to treat neurodegenerative lysosomal storage disease
  • 2009: Initiated first-ever clinical trial to evaluate human neural stem cells as a potential treatment for a myelination disorder

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