Publications

The following is a select list of peer-reviewed publications and poster presentations associated with StemCells, Inc. therapeutic product development programs. These publications can also be accessed online at PubMed.gov.*

Publications marked with an asterisk (*) are available on PubMed.gov as abstract only.

Overview of Clinical Translation

Tsukamoto, A., Uchida, N., Capela, A., Gorba, T., Huhn, S., Clinical translation of human neural stem cellsStem Cell Research & Therapy 4:102, 2013.

Aboody, K., Capela, A., Niazi, N., Stern, J.H. & Temple, S., Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone. Neuron 70:597-613, 2011.

Retinal Disorders / Age-related Macular Degeneration (AMD)

Cuenca N, Fernandez-Sanchez L, McGill TJ, Lu B, Wang S, Lund R, Huhn S, Capela A., Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration. Investigative Ophthalmology & Visual Science 54:6745-6756, 2013.

McGill TJ, Cottam B, Lu B, Wang S, Girman S, Tian C, Huhn SL, Lund RD, Capela A., Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration. The European Journal of Neuroscience 35:468-477, 2012. 

*McGill TJ, et al., Long-term Efficacy of Human Central Nervous System Stem Cells (hCNS-SCns) Transplanted into the Subretinal Space of RCS Rats. Association for Research in Vision (ARVO) Annual Meeting, Fort Lauderdale, FL 2009.

Spinal Cord Injury

Sontag, C., Uchida, N., Cummings, BJ, Anderson, AJ., Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports 2, 620-632, 2014.

Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson AJ, Cummings BJ., Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Translational Medicine 2:731-744, 2013.

Piltti, K.M., Salazar, D.L., Uchida, N., Cummings, B.J. & Anderson, A.J. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Translational Medicine 2:204-216, 2013.

Piltti, K.M., Salazar, D.L., Uchida, N., Cummings, B.J. & Anderson, A.J. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Translational Medicine 2:961-974, 2013.

Salazar D.L., Uchida N., Hamers F.P., Cummings B.J., Anderson A.J., Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS ONE, 5:e12272, 2010.

Hooshmand M.J., Sontag C.J., Uchida N., Tamaki S., Anderson A.J., Cummings B.J., Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS ONE, 4:e5871, 2009.

Cummings B.J., Uchida N., Tamaki S.J., Anderson A.J., Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function.Neurological Research, 28:474-481, 2006.

Cummings B.J., Uchida N., Tamaki S.J., Salazar D.L., Hooshmand M., Summers R., Gage F.H., Anderson A.J., Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. PNAS, 102:14069-14074, 2005.

Rare Genetic Disorders

Myelination Disorders

Gupta N., Henry R.G., Strober J., Kang S.M., Lim D.A., Bucci M., Caverzasi E., Gaetano L., Mandelli M.L., Ryan T., et al, Neural stem cell engraftment and myelination in the human brain. Science Translational Medicine 4:155ra137, 2012.

Uchida N., Chen K., Dohse M., Hansen K.D., Dean J., Buser J.R., Riddle A., Beardsley D.J., Wan Y., Gong X., et al, Human neural stem cells induce functional myelination in mice with severe dysmyelination. Science Translational Medicine 4:155ra136, 2012.

Lysosomal Storage Disorders / Neuronal Ceroid Lipofuscinosis (NCL), a.k.a. Batten Disease

Selden N.R., Al-Uzri A., Huhn S.L., Koch T.K., Sikora D.M., Nguyen-Driver MD, Guillaume D.J., Koh J.L., Gultekin S.H., Anderson J.C., et al, Central nervous system stem cell transplantation for children with neuronal ceroid lipofuscinosis. Journal of Neurosurgery:Pediatrics 11:643-652, 2013.

*Jacobs Y, et al., Long-term survival and migration of allogeneic human central nervous system stem cells following intracerebral transplantation in neuronal ceroid lipofuscinosis. ISSCR 2011 Annual Meeting, Toronto, ON, Canada, June 2011.

Tamaki S, et al., Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell, 5:310-319, 2009.

Guillaume DJ, et al., Cellular Therapy for Childhood Neurodegenerative Disease. Part I: Rationale and Pre-clinical Studies. Neurosurgical Focus, June 2008.

Selden NR, et al., Cellular Therapy for Childhood Neurodegenerative Disease. Part II: Clinical Trial Design and Implementation. Neurosurgical Focus, June 2008.

Other Indications

Stroke

Horie N, et al., Transplanted stem cell-secreted VEGF effects post-stroke recovery, inflammation, and vascular repair.  Stem Cells, 29:274-285, 2011.

Kelly S., Bliss T.M., Shah A.K., Sun G.H., Ma M., Foo W.C., Masel J., Yenari M.A., Weissman I.L., Uchida N., et al, Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex, PNAS, 101:11839-11844, 2004.

Varicella-zoster Virus (VSV)

Baiker, A. et al. Varicella-zoster virus infection of human neural cells in vivo. PNAS 101:10792-10797, 2004.

Foundational Research

Uchida, N. MicroRNA-9 controls a migratory mechanism in human neural progenitor cells. Cell stem cell 6:294-296, 2010.

Tamaki S., Eckert K., He D., Sutton R., Doshe M., Jain G., Tushinski R., Reitsma M., Harris B., Tsukamoto A., et al, Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. Journal of Neuroscience Research, 69:976-986, 2002.

Tamaki S, et al., Engraftment of sorted/expanded human CNS stem cells from fetal brain. Journal of Neuroscience Research, 2002.

Uchida N., Buck D.W., He D., Reitsma M.J., Masek M., Phan T.V., Tsukamoto A.S., Gage F.H., Weissman I.L., Direct isolation of human central nervous system stem cells. PNAS 97:14720-14725, 2000.