The following is a select list of peer-reviewed publications and poster presentations associated with StemCells therapeutic product development programs. These publications can also be accessed online at PubMed.gov.
HuCNS-SC® Cells – Miscellaneous
Tamaki S, et al., Engraftment of Sorted/Expanded Human CNS Stem Cells from Fetal Brain. Journal of Neuroscience Research, August 2002.
Uchida N, et al., Direct Isolation of Human Neural Stem Cell from Fetal Brain by Cell Sorting. PNAS, December 2000.
Lysosomal Storage Disorders / Neuronal Ceroid Lipofuscinosis (NCL or Batten disease)
Jacobs Y, et al., Long-term Survival and Migration of Allogeneic Human Central Nervous System Stem Cells following Intracerebral Transplantation in Neuronal Ceroid Lipofuscinosis. ISSCR 2011 Annual Meeting, Toronto, ON, Canada, June 2011.
Tamaki S, et al., Neuroprotection of Host Cells by Human Central Nervous System Stem Cells in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis. Cell Stem Cell, September 2009.
Guillaume DJ, et al., Cellular Therapy for Childhood Neurodegenerative Disease. Part I: Rationale and Preclinical Studies. Neurosurgical Focus, June 2008.
Selden NR, et al., Cellular Therapy for Childhood Neurodegenerative Disease. Part II: Clinical Trial Design and Implementation. Neurosurgical Focus, June 2008.
McGill TJ, et al., Long-term Efficacy of Human Central Nervous System Stem Cells (hCNS-SCns) Transplanted into the Subretinal Space of RCS Rats. Association for Research in Vision (ARVO) 2009 Annual Meeting, Fort Lauderdale, FL.
Spinal Cord Injury
Salazar DL, et al., Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal Cord Injury NOD-scid Mouse Model. PLoS ONE, August 2010.
Hooshmand M, et al., Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal CordInjury: Correlation of Engraftment with Recovery. PLoS ONE, June 2009.
Cummings BJ, et al., Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function.Neurological Research, July 2006.
Cummings BJ, et al., Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.PNAS, September 19, 2005.
Horie N, et al., Transplanted Stem Cell-secreted VEGF Effects Post-stroke Recovery, Inflammation, and Vascular Repair. Stem Cells, January 14, 2011.
Guzman R, et al., Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. PNAS, June 12, 2007.
Kelly S, et al., Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex, PNAS, August 10, 2004.
Austin TW, et al., Biological properties of prospectively isolated human adult liver engrafting cells, SC8+ hLEC, transplanted into a mouse model of genetically-based chronic liver disease. ISSCR 2010 Annual Meeting, San Francisco, CA.
Enns, GM, Millan MT. Cell-Based Therapies for Metabolic Liver Disease. Mol Genet Metab. 2008 Sep-Oct; 95(1-2):3-10. Epub 2008 Jul 18.
Xiong A, et al., Isolation of Human Fetal Liver Progenitors and their Enhanced Proliferation by 3-Dimensional Co-culture with Endothelial Cells. Tissue Eng Part A. 2008 Jun;14(6):995-1006.
Tools & Technologies
Gorba T, et al., Validation of adherent, non-immortalized mouse and human neural stem cell technology for scale-up, automated culture and high-throughput screening in a cell proliferation/viability assay, ISSCR 2010 Annual Meeting, San Francisco, CA.
Gorba T, et al., Generation of induced pluripotent stem cells from mouse neural stem cells by transient plasmid nucleofection reprogramming in chemical inhibitor (iSTEM®) culture medium, 2009 World Stem Cell Summit, Baltimore, MD.
Zaibak F, et al., Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres. BMC Biotechnol. Dec 15;9:101, 2009.
Thomson H, Bioprocessing of embryonic stem cells for drug discovery. Trends Biotechnol. 2007 May;25(5):224-30. Epub 2007 Mar 26.
Munsie M, et al., Transgenic systems in nuclear reprogramming. Methods Mol Biol. 2006;325:115-28.
Mee PJ, et al., Embryonic stem cells as a source of differentiated neural cells for pharmacological screens. Methods Mol Biol. 2006;329:353-69.
Gorba T, Allsopp TE, Pharmacological potential of embryonic stem cells. Pharmacol. Res. 2002; 47:269-78.
Munsie M, et al., Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei. Curr Biol 2000; 10(16):989-992.