Cells & Cell Lines
At the core of our platform is a range of proprietary cells and cell lines that either directly represent, or can be differentiated to represent, the actual human target cell for a pharmacologic product development program. Such cells and cell lines may be utilized as the “substrate” in basic assays, for compound library screening, more sophisticated in vitro characterization assays and in our well-established immuno-deficient in vivo rodent models.
- Human embryonic stem (ES) cell lines
- Human neural stem (NS) cell lines
- Human adherent NS cell lines
- Human iPS-derived NS cell line
- Human liver engrafting cells (hLEC)
Our platform also incorporates rodent cell and cell line counterparts to these human cells and cell lines, thereby enabling cross-species comparison of in vitro and in vivo pharmacology and mechanism-of-action studies.
- Mouse adherent NS cell lines
- Mouse ES cell line
- Rat ES cell line
- Rat ES-derived NS cell line
Cell lines may also be modified to incorporate reporter gene constructs.