SC Proven Cell Culture Products

SC Proven cell culture products enable the standardized and reproducible production and propagation of human and rodent pluripotent and tissue-specific stem cells. Scientists around the globe rely on SC Proven cell culture products for:

  • Derivation
  • Re-programming

  • Maintenance

  • Expansion

  • Differentiation

Our Less-is-More Approach to Cell Culture

Stem and progenitor cells require specific conditions in which to survive and thrive. Researchers therefore need specialized cell culture “tools” that enable the derivation, growth, maintenance and manipulation of these sensitive cells. In addition to the limited quantity and quality of cells available to them, one of the greatest challenges facing both researchers and potential developers of cell-based therapeutics is how to reliably expand – or grow – stem cell lines without altering their nature.

Focus on Small Molecule-based Cell Culture Technology

Our expertise in cell biology and stem cell technology has enabled us to commercialize and develop more refined and less complex cell culture products to optimize the derivation, growth, maintenance and differentiation of stem cells. In seeking to meet the new demands of academic and pharmaceutical research and regulatory agencies for more defined and consistent stem cell culture reagents, we have in-licensed small molecule inhibitor-based media formulations that are completely free of serum and other ill-defined components, which are known sources of undesirable agents affecting stem cell performance.

Ground State Maintenance

Stem cells and progenitor cells, by definition, have a propensity for differentiation into other types of cells — hence their potential for repairing or restoring tissues and functionality. Maintaining the potency of stem and progenitor cells – i.e., maintaining them in their “ground state” by inhibiting their natural tendency to differentiate into other cell types – has been an ongoing challenge for scientists. It has been standard industry practice to use animal-derived cytokines to regulate differentiation. Cytokines are proteins produced by cells to signal or regulate certain actions such as growth or differentiation. The addition of cytokines can affect the results of studies and assays performed in the process of drug discovery and development.

StemCells has moved away from the use of cytokines as regulating agents, and instead uses only small molecules, which can be readily identified and, therefore, facilitate more accurate research, drug discovery and development.

Advance Your Stem Cell Research with SC Proven Products

SC Proven® products undergo rigorous quality control procedures before release. The SC Proven stamp is your assurance that every product bearing our trademark meets impeccable quality standards.

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Photo of Paul

Paul Bello, PhD
Head, Media Systems

Our ‘less is more’ approach to cell culture technology is pivotal not only in increasing our understanding of stem cells themselves, but also in advancing research both in the direct transplantation of stem cells as therapeutics and in using stem cells as superior disease models to accelerate drug discovery and development.
When I first came to Stem Cell Sciences (before the company was acquired by StemCells, Inc.), our ultimate goal was to cultivate human stem cells for transplantation as therapeutic agents. True stem cells, by definition, have an extraordinary propensity for differentiation into all other cell types of the body — hence their potential utility for repairing or restoring tissues and organ function. To harness this potential, we must first be able to derive the stem cells and expand (or grow) stem cell lines, and then be able to maintain them in their naïve ‘ground state’ — in other words, prevent them from differentiating before we put them to use.
As our work progressed, our quest became focused on finding better formulations for cell culture media, reagents and supplements — the 'soup' that sustains the living stem cells. The standard in the field had been to find and add more biological ingredients to this soup, in order to achieve the extraordinarily specialized conditions required to maintain stem cells in their ground state. But adding more variables results in less controlled conditions. So we adopted a new paradigm for culturing stem cells – one that seeks to try and eliminate the need to add animal-derived growth factors or cytokines (proteins produced by cells to signal or regulate certain actions, such as growth or differentiation). Our understanding of key stem cell biological pathways has led to inhibitor-based technology utilizing small, clearly defined molecules rather than complex supplements. This makes the soup far more refined. The less complex we can make the cell culture conditions, the more precise we can make our studies.”

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Our ‘less is more’ approach to cell culture technology is pivotal not only in increasing our understanding of stem cells themselves, but also in advancing research both in the direct transplantation of stem cells as therapeutics and in using stem cells as superior disease models to accelerate drug discovery and development.
Photo of PaulWhen I first came to Stem Cell Sciences (before the company was acquired by StemCells, Inc.), our ultimate goal was to cultivate human stem cells for transplantation as therapeutic agents. Read the full story…

Paul Bello, PhD
Head, Media Systems

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Millipore Licensed Media

We have granted Millipore licenses for the manufacture, distribution and marketing of several cell culture media products and reagents for serum-free culture of ES cells. Learn more…

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